| ACROSS |
| 1. | Virtual Memory System (abbr.) |
| 4. | Assist |
| 7. | Nobel Price-winning Portuguese psychiatrist Moniz |
| 11. | Presage |
| 13. | Storage container |
| 14. | Unable to walk |
| 15. | Soaks |
| 16. | Person who has lied or who lies repeatedly |
| 18. | International Recording Media Association (abbr.) |
| 19. | Enemy |
| 21. | _ moment's notice (2 wds.) |
| 24. | Two (Sp.) |
| 25. | _-fi |
| 28. | Volcano in Japan |
| 30. | Fenced enclosure |
| 31. | Compass dir. |
| 32. | Passive Optical Network (abbr.) |
| 33. | It would |
| 34. | Within a short period |
| 36. | The first octave above the treble staff |
| 37. | A young scorpion |
| 40. | Spanish title |
| 42. | At this time |
| 43. | Nonscientific branch of learning |
| 46. | Device for capturing images |
| 49. | Electrically charged atom |
| 51. | Large genus of African trees bearing kola nuts |
| 52. | Lion |
| 55. | E Mali city |
| 56. | Expresson of surprise, comprehension, or mock astonishment |
| 58. | Symbol (abbr.) |
| 60. | Night before a holiday |
| 61. | Increase |
| 62. | Auto club (abbr.) |
| 63. | Rowing implement |
| 64. | American Medical Association (abbr.) |
| 66. | Take up and hold, as by absorption or adsorption |
| 68. | In the same book, chapter, page, etc. (short form) |
| 71. | Religious women |
| 75. | Otherwise |
| 76. | Exercise |
| 77. | Angers |
| 78. | Perceives with the eye |
| 79. | June honoree |
| 80. | Mamie's husband |
|
| DOWN |
| 1. | Solemn pledge |
| 2. | Madame (abbr.) |
| 3. | Arrange properly for use |
| 4. | Most capable |
| 5. | One more than two |
| 6. | Two long chains of nucleotides twisted into a double helix |
| 7. | Biblical high priest |
| 8. | Place where plants grow |
| 9. | An ancient kingdom east of the Jordan River |
| 10. | Gospel singer Marvin |
| 12. | National Science Foundation (abbr.) |
| 17. | Strike |
| 20. | Fr. "Yes" |
| 22. | Trial |
| 23. | Small Philippine buffalo |
| 25. | Health resort |
| 26. | Lacking warmth |
| 27. | To the inside or interior of |
| 29. | A city of northeast Italy northeast of Venice |
| 35. | Mouth or opening |
| 38. | And not |
| 39. | Long, narrow, usually shallow trough between ridges on a beach, running parallel to the coastline |
| 41. | Non-commissioned officer (abbr.) |
| 44. | Port city in Latvia |
| 45. | Frog relative |
| 47. | In addition |
| 48. | A member of an American Indian people of Yucatan and Belize and Guatemala |
| 50. | Lower and raise head in agreement |
| 51. | Rough |
| 53. | Eluded |
| 54. | Original Equipment Manufacturer (abbr.) |
| 56. | Fertile tracts in a desert |
| 57. | White Person, in Hawaii |
| 59. | Magnetic Resonance Imaging (abbr.) |
| 65. | Black tropical American cuckoo |
| 67. | Egyptian god of music and revelry and the guardian deity of women in labor |
| 69. | Partially opened flower |
| 70. | Retirement account (abbr.) |
| 72. | Universal Resource Identifier |
| 73. | Italian singer-songwriter Filippo Neviani |
| 74. | Compass dir. |