| ACROSS |
| 1. | Cuckoo |
| 4. | Groovy apt. |
| 7. | Oregon Treasure Trail Society (abbr.) |
| 11. | Assistant |
| 13. | (biochemistry) Long linear polymer of nucleotides found in a cell |
| 14. | A young zebra |
| 15. | Smallest unit of an element |
| 16. | Likelihood |
| 18. | Prong on a fork |
| 19. | Large vase that usually has a pedestal or feet |
| 21. | Retirement account (abbr.) |
| 24. | Hat (slang) |
| 25. | Mouth or opening |
| 28. | It would |
| 30. | Writing instrument |
| 31. | Curvy letter |
| 32. | Fluid product of inflammation |
| 33. | A female weasel |
| 34. | A single undivided whole |
| 36. | Neckwear |
| 37. | Crowded into |
| 40. | Zimbabwe AIDS Network (abbr.) |
| 42. | Air pressure measure (abbr.) |
| 43. | Oval reproductive body of a fowl |
| 46. | A group of whales |
| 49. | Diode which emits light from the p-n junction |
| 51. | Pertaining to black traditions or culture |
| 52. | Sodium hydroxide |
| 55. | Fr. "Yes" |
| 56. | Experiment locale |
| 58. | Biblical high priest |
| 60. | It is so |
| 61. | Madame (abbr.) |
| 62. | Snakelike fish |
| 63. | Dripping |
| 64. | Perceive with the eye |
| 66. | Ancient Greek god of war |
| 68. | Set or collection |
| 71. | Without |
| 75. | Regional Information Sharing System (abbr.) |
| 76. | Sliced dessert |
| 77. | It was, poetically |
| 78. | Remaining after all deductions |
| 79. | Title for a knight |
| 80. | Supplement with great effort |
|
| DOWN |
| 1. | Auto club (abbr.) |
| 2. | A young louse |
| 3. | A language that is deliberately created for a specific purpose |
| 4. | Right away |
| 5. | Plus |
| 6. | Male parent |
| 7. | Often (poetically) |
| 8. | Bathroom plumbing fixture |
| 9. | Ancient Egyptian city in the eastern delta of the Nile River |
| 10. | Vehicles mounted on runners, pulled by horses or dogs |
| 12. | Australian flightless bird |
| 17. | Small drink |
| 20. | To free from |
| 22. | Reuben's nickname |
| 23. | Queen of England 1702–14 |
| 25. | Choose |
| 26. | Volcano in Colombia |
| 27. | At sea |
| 29. | Volcano in Sumatra |
| 35. | Binary compound |
| 38. | Bear (Spanish) |
| 39. | A male goat |
| 41. | National Science Foundation (abbr.) |
| 44. | Take by theft |
| 45. | Perennial herbaceous plant in the rose family Rosaceae |
| 47. | Group working together |
| 48. | Opening into or through something |
| 50. | Expire |
| 51. | Most capable |
| 53. | Last past |
| 54. | Compass dir. |
| 56. | Acquire or gain knowledge or skills |
| 57. | Nest on high |
| 59. | It is |
| 65. | Eastern Standard Time (abbr.) |
| 67. | Supersonic Transport (abbr.) |
| 69. | Uninterruptible Power Supply (abbr.) |
| 70. | One more than two |
| 72. | Deep reverence |
| 73. | A female yak |
| 74. | Compass dir. |
