| ACROSS |
| 1. | Relating to the mouth |
| 5. | Ocean |
| 8. | Hat (slang) |
| 11. | A female goose |
| 12. | Gilded |
| 13. | Wedding promise |
| 14. | A republic consisting of 26 of 32 counties comprising the island of Ireland |
| 16. | Among |
| 17. | Cask |
| 18. | Two long chains of nucleotides twisted into a double helix |
| 19. | Having or resembling wings |
| 22. | Master of Engineering Administration (abbr.) |
| 23. | Nobel Price-winning Portuguese psychiatrist Moniz |
| 24. | Snakelike fish |
| 25. | Goes without food and/or water |
| 26. | Ancient city of Etruria north of modern-day Rome, Italy |
| 28. | Commotion |
| 30. | Higher Education for Development (abbr.) |
| 32. | Disposition, character, values of a culture |
| 34. | A really long time |
| 35. | Lower and raise head in agreement |
| 37. | Single |
| 38. | Ancient Roman robes |
| 41. | Male child |
| 43. | Object-Oriented Software Engineering (abbr.) |
| 44. | Eastern Russia river; Laptev Sea tributary |
| 45. | Administered medicine |
| 47. | Strike |
| 48. | Largest and southernmost island in the Marianas |
| 49. | Everything |
| 50. | Respote |
| 51. | Religious belief of African origin involving witchcraft and sorcery |
| 54. | Three (prefix) |
| 55. | Musical group of three |
| 58. | An important question that is in dispute |
| 60. | The 18th letter of the Arabic alphabet |
| 61. | Member of an aboriginal population of northernmost Japan |
| 62. | Small island |
| 63. | Paper or plastic container |
| 64. | June honoree |
| 65. | Diluted with white |
|
| DOWN |
| 1. | Wrote a lyric poem |
| 2. | Water falling in drops from the sky |
| 3. | American Motorcycle Racing Association (abbr.) |
| 4. | Area sheltered from the wind |
| 5. | Monetary unit of Kyrgyzstan |
| 6. | Biblical high priest |
| 7. | Find the sum of |
| 8. | Probability |
| 9. | The main thing one is thinking about |
| 10. | A male wolf |
| 12. | Slender fish |
| 15. | Droops |
| 20. | Thin strip of wood or metal |
| 21. | NE Netherlands city |
| 22. | Confront |
| 23. | Hearing organ |
| 24. | First lady |
| 25. | A young trout |
| 27. | Charged particles |
| 28. | Arrange properly for use |
| 29. | Instrument |
| 31. | Two (Sp.) |
| 33. | Observe |
| 36. | Evade |
| 39. | Of or related to the anus |
| 40. | Plant excrement |
| 42. | Good sense |
| 43. | Original Equipment Manufacturer (abbr.) |
| 46. | Suttee (variant) |
| 49. | Operatic vocal solo |
| 50. | Right of Use (abbr.) |
| 51. | A peak of the Olympus Mountains in northern Greece |
| 52. | A male whale |
| 53. | Institute of Electrical and Electronics Engineers (abbr.) |
| 54. | Keyboard key |
| 55. | Bit |
| 56. | Research Institute of America (abbr.) |
| 57. | Indiana (abbr.) |
| 59. | Small drink |