| ACROSS |
| 1. | Pet locale |
| 4. | Mountains (abbr.) |
| 7. | Ancient Greek colony of southern Italy near the Gulf of Salerno |
| 11. | Raised platform |
| 13. | Organic radical derived from an aromatic compound by the removal of one hydrogen atom |
| 15. | Shout |
| 16. | Thin strip of wood or metal |
| 17. | Prong on a fork |
| 18. | Relaxation |
| 19. | Night before a holiday |
| 22. | Chief Executive Officer (abbr.) |
| 24. | Portuguese money of account (variant) |
| 25. | A female horse |
| 28. | Mamie's husband |
| 30. | Passive Optical Network (abbr.) |
| 32. | Mouth or opening |
| 33. | Master of Engineering Administration (abbr.) |
| 34. | Member of the Shoshonean people of Utah and Colorado and New Mexico |
| 35. | Small island |
| 36. | Russian ruler |
| 39. | Mouth, stomach, jaws, or gullet of a voracious animal |
| 42. | Egyptian god of music and revelry and the guardian deity of women in labor |
| 43. | Gospel singer Marvin |
| 44. | Observe |
| 46. | Nilotic language |
| 48. | Lodging establishments |
| 49. | 4-wheeled motor vehicle |
| 50. | Simplified Employee Pension (plan) (abbr.) |
| 52. | Thickening of tissue in the motor tracts of the lateral columns and anterior horns of the spinal cord |
| 55. | University of Rhode Island (abbr.) |
| 56. | Bank Draft (abbr.) |
| 57. | One more than two |
| 58. | Compass dir. |
| 59. | Separate the seeds from cotton |
| 61. | Gear tooth |
| 64. | A female yak |
| 66. | American National Standards Institute (abbr.) |
| 68. | Angers |
| 71. | Egg locale |
| 75. | A blast of a horn |
| 76. | Foreign minister of the Netherlands in the 1950s and 1960s |
| 77. | Sacs in ascomycetes in which the sexual spores are formed |
| 78. | Hearing organs |
| 79. | A group of partridges |
| 80. | Sigma Iota Epsilon (abbr.) |
|
| DOWN |
| 1. | Lipoprotein that transports cholesterol in the blood |
| 2. | Auto club (abbr.) |
| 3. | A group of snakes |
| 4. | Floor covering |
| 5. | Three (prefix) |
| 6. | Synchronize (abbr.) |
| 7. | Sight organ |
| 8. | Memorize |
| 9. | Otherwise |
| 10. | Toward shelter |
| 12. | A female animal or person |
| 14. | Area sheltered from the wind |
| 20. | Zeal |
| 21. | Make supply last |
| 23. | Elect |
| 25. | Tract of land included between two rivers |
| 26. | Satellite of Uranus |
| 27. | Taiwanese island in East China Sea |
| 29. | Consumed |
| 31. | Original Equipment Manufacturer (abbr.) |
| 34. | Exercise |
| 37. | Zimbabwe AIDS Network (abbr.) |
| 38. | Slender Brazilian palm |
| 40. | Saclike structure in which ascospores are formed |
| 41. | Erodes |
| 43. | Small drink |
| 45. | 4th largest of the Great Lakes |
| 47. | Order of Saint Francis (abbr.) |
| 51. | And so on (abbr.) |
| 53. | Flaplike covering |
| 54. | Title for a knight |
| 56. | Belgian painter/printmaker James (1860-1949) |
| 59. | Yard entry |
| 60. | Small Philippine buffalo |
| 62. | Petroleum |
| 63. | A young fly |
| 65. | _ tizzy (2 wds.) |
| 67. | It is |
| 69. | Compass dir. |
| 70. | Compass dir. |
| 72. | Curvy letter |
| 73. | _-fi |
| 74. | Make a knot |